H2N2V1, France, Analysis, bibRecord, 000213

Monoclonal antibody recognizing SLLTEVET epitope of M2 protein potently inhibited the replication of influenza A viruses in MDCK cells

Identifieur interne : 000213 ( France/Analysis ); précédent : 000212; suivant : 000214

Monoclonal antibody recognizing SLLTEVET epitope of M2 protein potently inhibited the replication of influenza A viruses in MDCK cells

Auteurs : Yongjin Wang [République populaire de Chine] ; Licheng Zhou [République populaire de Chine] ; Huiling Shi [République populaire de Chine] ; Hongwei Xu [République populaire de Chine] ; Hong Yao [République populaire de Chine] ; Xu Guang Xi [France] ; Tetsuya Toyoda [République populaire de Chine] ; Xiaoming Wang [République populaire de Chine] ; Tianhou Wang [République populaire de Chine]

Source :

Biochemical and Biophysical Research Communications [ 0006-291X ] ; 2009-07.

RBID : Hal:hal-02396507

English descriptors

mix :
- Influenza A, Inhibition, M2e8, Monoclonal antibody.

Abstract

The ectodomain of influenza A virus M2 protein (M2e) is composed of 24 amino acids and induces antibodies with inhibitory effect against a broad spectrum of influenza A subtypes in vitro and in vivo. Although relatively conserved, 21 M2e variants emerged in recent influenza A strains, most of the mutations appeared in the middle part of M2e domain. In this study, we characterized the in vitro inhibition efficacy of a monoclonal antibody (mAb) M2e8-7 recognizing the N terminus highly conserved epitope SLLTEVET (aa 2-9) which is common for both M1 and M2 proteins. Peptide binding assay showed that mAb M2e8-7 reacted strongly with M2e and 19 M2e variant peptides. The mAb M2e8-7 potently inhibited the replication of influenza A virus H1 and H3 subtypes in MDCK cells. Two important amino acids in M2e epitope, Threonine at position five and the Glutamic acid at position six, were identified to lead antibody-escaping variants. These results brought new insight in developing vaccine and therapeutic agents against influenza A virus infections.

Url:

https://hal.archives-ouvertes.fr/hal-02396507

DOI: 10.1016/j.bbrc.2009.04.129

Affiliations:

France, République populaire de Chine

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000213
to stream Hal, to step Curation: 000213
to stream Hal, to step Checkpoint: 000290
to stream Main, to step Merge: 001013
to stream Main, to step Curation: 001005
to stream Main, to step Exploration: 001005
to stream France, to step Extraction: 000213

Links to Exploration step

Hal:hal-02396507

Le document en format XML

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<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Influenza A</term>
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<front><div type="abstract" xml:lang="en">              <p>The ectodomain of influenza A virus M2 protein (M2e) is composed of 24 amino acids and induces antibodies with inhibitory effect against a broad spectrum of influenza A subtypes in vitro and in vivo. Although relatively conserved, 21 M2e variants emerged in recent influenza A strains, most of the mutations appeared in the middle part of M2e domain. In this study, we characterized the in vitro inhibition efficacy of a monoclonal antibody (mAb) M2e8-7 recognizing the N terminus highly conserved epitope SLLTEVET (aa 2-9) which is common for both M1 and M2 proteins. Peptide binding assay showed that mAb M2e8-7 reacted strongly with M2e and 19 M2e variant peptides. The mAb M2e8-7 potently inhibited the replication of influenza A virus H1 and H3 subtypes in MDCK cells. Two important amino acids in M2e epitope, Threonine at position five and the Glutamic acid at position six, were identified to lead antibody-escaping variants. These results brought new insight in developing vaccine and therapeutic agents against influenza A virus infections.</p>
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<affiliations><list><country><li>France</li>
<li>République populaire de Chine</li>
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<tree><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Yongjin" sort="Wang, Yongjin" uniqKey="Wang Y" first="Yongjin" last="Wang">Yongjin Wang</name>
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<name sortKey="Shi, Huiling" sort="Shi, Huiling" uniqKey="Shi H" first="Huiling" last="Shi">Huiling Shi</name>
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<name sortKey="Wang, Tianhou" sort="Wang, Tianhou" uniqKey="Wang T" first="Tianhou" last="Wang">Tianhou Wang</name>
<name sortKey="Wang, Xiaoming" sort="Wang, Xiaoming" uniqKey="Wang X" first="Xiaoming" last="Wang">Xiaoming Wang</name>
<name sortKey="Xu, Hongwei" sort="Xu, Hongwei" uniqKey="Xu H" first="Hongwei" last="Xu">Hongwei Xu</name>
<name sortKey="Yao, Hong" sort="Yao, Hong" uniqKey="Yao H" first="Hong" last="Yao">Hong Yao</name>
<name sortKey="Zhou, Licheng" sort="Zhou, Licheng" uniqKey="Zhou L" first="Licheng" last="Zhou">Licheng Zhou</name>
</country>
<country name="France"><noRegion><name sortKey="Xi, Xu Guang" sort="Xi, Xu Guang" uniqKey="Xi X" first="Xu Guang" last="Xi">Xu Guang Xi</name>
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Monoclonal antibody recognizing SLLTEVET epitope of M2 protein potently inhibited the replication of influenza A viruses in MDCK cells

Monoclonal antibody recognizing SLLTEVET epitope of M2 protein potently inhibited the replication of influenza A viruses in MDCK cells

Source :

English descriptors

Abstract

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